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Oral Monosodium Glutamate Differentially Affects Open-Field Behaviours, Behavioural Despair and Place Preference in Male and Female Mice

Author(s):

Onaolapo AY, Olawore OI, Yusuf FO, Adeyemo AM, Adewole IO and Onaolapo OJ*   Pages 1 - 16 ( 16 )

Abstract:


Background: The sex-differential effects of monosodium glutamate (MSG) on open-field behaviours, anxiety-related behaviour, behavioural despair, place-preference, and plasma/brain glutamate levels were assessed in adult mice, with a view to determining the possible sex-related differences in the response to MSG administration. Methods: Mice were assigned to three main groups (1-3), based on the models used to assess behaviours. Animals in group 1 were for the elevated-plus maze and tail-suspension paradigms, group 2 for the open-field and forced-swim paradigms, while mice in group 3 were for observation in the conditioned place preference paradigm. Mice in all the groups were further assigned into five treatment subgroups (each consisting of 10 males and 10 females), and administered vehicle (distilled water at 10 ml/kg) or one of four doses of MSG (20, 40, 80 and 160 mg/kg) daily for 6 weeks, following which they were exposed to the behavioural paradigms. At the end of the behavioural tests, the animals were sacrificed, and blood was taken for estimation of glutamate levels. The brains were also homogenised for estimation of glutamate levels. Result: MSG was associated with a dose-dependent reduction in locomotion in males and females (except at 160 mg/kg, male), an anxiolytic response in females, an anxiogenic response in males, and decreased behavioural despair in both sexes (females more responsive). Post-conditioning MSG-associated place-preference was significantly higher in females. Plasma/brain glutamate did not show significant differences between the sexes. Conclusion: In conclusion, repeated MSG administration alters a range of behaviours in a sex-dependent manner in mice.

Keywords:

Anxiolytic, Central inhibition, Depression, Glutamate, Sex, Stereotypy

Affiliation:

Behavioural Neuroscience/Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Behavioural Neuroscience/Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Behavioural Neuroscience/Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Behavioural Neuroscience/Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Behavioural Neuroscience/Neuropharmacology Unit, Department of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State, Behavioural Neuroscience/Neuropharmacology Unit, Department of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State



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