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Neurobehavioral Effects of β-Escin

Author(s):

Hayder M. Alkuraishy*, Ali I. Al-Gareeb, Ali K. Albuhadilly, Iman N. Al-Bajaji, Huda Jaber Alkuraishy and Marta Chagas Monterio   Pages 1 - 8 ( 8 )

Abstract:


Background: Aescin or β-escin is the main and active constituent of horse chest-nut seed (Aesculus hippocastanum) used for the treatment of inflammatory edema, venous in-sufficiency and ischemic ulcerations. Aescin has many actions due to induction of endothelial nitric oxide and prostaglandin F2-α production moreover; aescin antagonizes the effect of his-tamine and 5HT at receptor levels . Objective: The aim of the present study was to evaluate the neurobehavioral effects of aescin on normal healthy volunteers. Methods: A total number of 65 healthy participants with mean age of 21+1.1 years were re-cruited to study the effects of aescin on the neurobehavioral effects of normal healthy volun-teers compared to placebo. The neurobehavioral effects were assessed by psychomotor per-formances and sensorimotor reaction, cortical arousal and central integrity processes and as-sessment of memory capacity. Results: Placebo produced insignificant amelioration of TRT and RRT p>0.05, with mild significant effect on MRT p=0.03. Aescin produced a significant effect in the amelioration of psychomotor performances and sensorimotor reaction p=0.0001. Regarding the differential effect of placebo and aescin on the cortical arousal and central integrity processes, placebo il-lustrated insignificant effect at p>0.05 whereas; aescin showed mild significant effect on crit-ical fusion frequency (CFFA) p<0.05 and highly significant effect on the other parameters p<0.01 except for critical-fusion frequency threshold when aescin illustrated insignificant ef-fect at p>0.05. Aescin illustrated significant acceleration of ІІ-back WMA, ІІІ-back WMA and Second trial short-term memory (STM) at p<0.01 compared to the placebo effect. Conclusion: short-term therapy with aescin improves the neurobehavioral effects on healthy volunteers.

Keywords:

neurobehavioral, Aescin , placebo

Affiliation:

Assist Professor in Department Of Pharmacology, Toxicology and Medicine College of Medicine Al-mustansiriya University P.O. Box 14132, Baghdad, Assist Professor in Department Of Pharmacology, Toxicology and Medicine College of Medicine Almustansiriya University P.O. Box 14132, Baghdad , Lecturer in Department Of Pharmacology, Toxicology and Medicine College of Medicine Almustansiriya University P.O. Box 14132, Baghdad, Lecturer in Department Of Pharmacology, Toxicology and Medicine College of Medicine Almustansiriya University P.O. Box 14132, Baghdad, Lecturer in Department of Biochemistry, College of Pharmacy, Almustansiriya University, Baghdad, Professor and Research Federal University of Para , Belem • Faculty of Pharmacy Belem



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