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Systemic Injections of Primidone Cause Wake-Inducing Effects in Rats

Author(s):

Mireille Salas-Crisostomo, Maria Franco-Tormo, Niurka Trujillo-Paredes, Gloria Arankowsky-Sandoval, Oscar Arias-Carrion, Sergio Machado, Eric Murillo-Rodriguez and Eric Murillo-Rodríguez   Pages 1 - 7 ( 7 )

Abstract:


Background: Essential tremor (ET) is a disease present in neurodegenerative disorders, such as Parkinson´s disease. Besides the motor dysfunction, ET also causes sleep problems, includ-ing excessive daytime sleepiness. To manage ET, several compounds are prescripted, such as primidone. However, no evidence is available regarding the effects of primidone on sleep. Objective: We analyzed the effects of systemic injections of primidone on sleep in rats. Method: Rats with sleep electrodes received different doses of primidone (0, 5, 10 or 50mg/Kg, i.p.) at the beginning of the lights-on period. Next, the effects of primidone on the states of vigilance were characterized. Results: At the highest dose of primidone (50mg/Kg), animals displayed an increase in wakeful-ness (W) whereas slow wave sleep (SWS) and rapid eye movement sleep (REMS) were de-creased. In addition, sleep parameters such as the number of bouts, mean duration and latency were affected in primidone-treated animals. In this regard, the drug caused an enhancement in the number of bouts of W and SWS while the number of events of REMS showed a diminution. Re-garding the mean duration, we found that SWS was decreased after primidone treatments where-as W and REMS remained with no statistical changes. Lastly, the latency of SWS was enhanced in primidone-treated animals while no statistical changes were found in REMS. Conclusion: Our findings demonstrate that primidone, a drug that is used to control ET, pro-vokes wake-inducing effects in rats.

Keywords:

Alertness, drug, essential tremor, Parkinson´s disease, stimulant

Affiliation:

Moleculares e Integrativas. Escuela de Medicina Division Ciencias de la Salud. Universidad Anahuac Mayab. Merida, Laboratorio de Neurociencias, Universidad Anahuac Mayab, Laboratorio de Neurociencias Moleculares e Integrativas. Escuela de Medicina Division Ciencias de la Salud, Universidad Anahuac Mayab, Escuela de Medicina, Division Ciencias de la Salud, Universidad Autonoma de Yucatan, Centro de Investigaciones Regionales ``Dr. Hideyo Noguch``, Unidad de Trastornos del Movimiento y Sueno (TMS). Hospital General ``Dr. Manuel Gea González``, Institute of Psychiatry of Federal University of Rio de Janeiro. Laboratory of Panic and Respiration, Universidad Anahuac Mayab, Laboratorio de Neurociencias Moleculares e Integrativas. Escuela de Medicina Division Ciencias de la Salud, Universidad Anahuac Mayab, Laboratorio de Neurociencias Moleculares e Integrativas Escuela de Medicina



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