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Role of Calcium Channels in Bipolar Disorder

[ Vol. 6 , Issue. 2 ]

Author(s):

Stasia D'Onofrio, Susan Mahaffey and Edgar Garcia-Rill*   Pages 122 - 135 ( 14 )

Abstract:


Bipolar disorder is characterized by a host of sleep-wake abnormalities that suggests that the reticular activating system (RAS) is involved in these symptoms. One of the signs of the disease is a decrease in high frequency gamma band activity, which accounts for a number of additional deficits. Bipolar disorder has also been found to overexpress neuronal calcium sensor protein 1 (NCS-1). Recent studies showed that elements in the RAS generate gamma band activity that is mediated by high threshold calcium (Ca2+) channels. This minireview provides a description of recent findings on the role of Ca2+ and Ca2+ channels in bipolar disorder, emphasizing the involvement of arousal-related systems in the manifestation of many of the disease symptoms. This will hopefully bring attention to a much-needed area of research and provide novel avenues for therapeutic development.

Keywords:

Arousal, Ca2+ channels, gamma oscillations, lithium, N-type, P/Q-type, cAMP/PKA, CaMKII.

Affiliation:

Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR

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