Lee Hsien Siang, Alina Arulsamy, Yeong Keng Yoon and Mohd. Farooq Shaikh*
Epilepsy is a devastating neurological disorder. Current anti-convulsant drugs are only effective in about 70% of patients, while the rest remain drug-resistant. Thus, alternative methods have been explored to control seizures in these drug-resistant patients. One such method may be through the utilization of fruit phytochemicals. These phytochemicals have been reported to have beneficial properties such as anti-convulsant, anti-oxidant and anti-inflammatory activities. However, some fruits may also elicit harmful effects. This review aims to summarize and elucidate the anti- or pro- convulsant effects of fruits used in relation to seizures, in hopes to provide a good therapeutic reference to epileptic patients and their carers. Three databases; SCOPUS, ScienceDirect and PubMed were utilized for the literature search. Based on the PRISMA guidelines, a total of 40 articles were selected for critical appraisal in this review. Overall, the extracts and phytochemicals of fruits managed to effectively reduce seizure activities in various preclinical seizure models, acting mainly through the activation of the inhibitory neurotransmission and blocking the excitatory neurotransmission. Only star fruit has been identified as a pro-convulsant fruit, which was attributed to the its caramboxin and oxalate compounds. Future studies should focus more on utilizing these fruits as possible treatment strategies for epilepsy.
epilepsy, drug-resistant, fruit extract, anti-seizure, pro-convulsant, anti-oxidant
School of Science, Monash University Malaysia, Bandar Sunway, Selangor, Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, School of Science, Monash University Malaysia, Bandar Sunway, Selangor, Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor